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Bhattacharjee, Ananya
- Pharmacodynamic Interaction of Green Tea Extract with Hydrochlorothiazide against Cyclophosphamide‑Induced Myocardial Damage
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Toxicology International (Formerly Indian Journal of Toxicology), Vol 21, No 2 (2014), Pagination: 196-202Abstract
Objective: Treatment of ischemic hypertensive patients with hydrochlorothiazide can precipitate cardiac arrhythmias. Green tea by virtue of its antioxidant potential is responsible for cardio‑protective activity. The present study was undertaken to evaluate the pharmacodynamic interaction of green tea extract with hydrochlorothiazide against cyclophosphamide‑induced myocardial toxicity. Materials and Methods: Rats were treated with high (500 mg/kg, p.o.) and low (100 mg/kg, p.o.) dose of green tea extract in alone and interactive groups for 10 days. Standard, high, and low dose of interactive groups received hydrochlorothiazide (10 mg/kg, p.o.) for last 7 days. Apart from normal control, all other groups were subjected to cyclophosphamide (200 mg/kg, i.p.) toxicity on day first and the effects of different treatments were evaluated by changes in electrocardiographic parameters, serum biomarkers, and tissue antioxidant levels. Apart from that, lipid profile and histological studies were also carried out. Results: Compared to cyclophosphamide control group, both high and low dose of green tea exhibited significant decrease in serum biomarkers and increase in tissue antioxidant levels. Green tea treatment was also responsible for significant improvement in echocardiography (ECG) parameter, lipid profile, and histological score. Incorporation of high and low dose of green tea with hydrochlorothiazide‑exhibited significant protection compared to hydrochlorothiazide‑alone‑treated group. Conclusion: The present findings clearly suggested that green tea extract dose dependently reduces cyclophosphamide‑induced myocardial toxicity. Green tea when combined with hydrochlorothiazide can reduce the associated side effects and exhibits myocardial protection.Keywords
Cyclophosphamide, green tea, hydrochlorothiazide- Nephroprotective Properties of Natural Herbs: A Systemic Review
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1 Department of Pharmacology, Srinivas College of Pharmacy, Valachil, Mangalore., IN
1 Department of Pharmacology, Srinivas College of Pharmacy, Valachil, Mangalore., IN
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Asian Journal of Research in Pharmaceutical Sciences, Vol 12, No 1 (2022), Pagination: 52-56Abstract
Nephrotoxicity is the most prevalent toxicity which is related to the organ called Kidney. Nephrotoxicity occurs when body get exposed to a drugs or toxic metabolites. A number of synthetic, therapeutically active medicinal agents such as aminoglycosides antibiotic, chemotherapeutic agents and NSAIDS may affects urinary system resulting in acute renal failure, nephritis and other kidney related disease. Medicinal plants potentially possess most prominent role in the treatment of kidney related disorders and helpful in the development of effective therapy for kidney problems. Medicinal herbs are rich source of phytoconstituents, so the presence of some bioactive compounds such as flavonoids, steroids, phenols, alkaloids shows potent Nephroprotective properties towards to nephrotoxicity. In this current review aimed to illustrate a list of recent medicinal herbs act as Nephroprotective agents.Keywords
Medicinal plants, Nephrotoxicity, Nephroprotective agents, Phytoconstituents, Renal disease.References
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